OpenClinica has a flexible architecture that can run on numerous infrastructure combinations. General system recommendations are as follows:
Single server environment hardware recommendation (OpenClinica and PostgreSQL Databases reside on the same server):
Minimum:
Linux (RedHat 6/7.x or CentOS 6/7.x)
CPU: Quad core 2GHz+ CPU
RAM: 4GB
Disk space: 100GB
Recommended:
Linux (RedHat 6/7x or CentOS 6/7.x)
CPU: Quad core 2GHz+ CPU
RAM: 16GB
Disk space: 500GB
Multiple-server environment hardware recommendation (OpenClinica and PostgreSQL Databases reside on separate servers)
Minimum:
Linux (RedHat 6/7.x or CentOS 6/7.x)
CPU: Quad core 2GHz+ CPU
RAM: 2GB (OpenClinica), 2GB (PostgreSQL/Database)
Disk space: 100GB
Recommended:
Linux (RedHat 6/7.x or CentOS 6/7.x)
CPU: Quad core 2GHz+ CPU
RAM: 8GB (OpenClinica), 4GB (PostgreSQL/Database)
Disk space: 500GB
Recent production versions of OpenClinica have been verified to run on the following components:
| Version | Server OS | Database | Application Server | Language | Memory | Disk | Client Browser |
| 3.10 – 3.14 | RHEL/CentOS Windows 2012, Windows 2008, | Postgres 9.5.x (recommended) Postgres 8.4 | Apache Tomcat 7.0.x | JDK 7 | 2GB | 20GB | IE 11+ Firefox 30.0+ |
| 3.6 – 3.9 | RHEL/CentOS Ubuntu 12.04 Windows 2012, Windows 2008, | Postgres 8.4 | Apache Tomcat 7.0.x | JDK 7 | 2 GB | 20GB | IE 11+ Firefox 30.0+ |
| 3.4, 3.5 | RHEL/CentOS Ubuntu 12.04 Windows 2012, Windows 2008, Windows 2003 R2 or above | Postgres 8.4 | Apache Tomcat 7.0.x | JDK 7 | 2 GB | 2 GB | IE 11+ Firefox 30.0 |
| 3.3 | RHEL/CentOS Windows 2003 R2 or above Ubuntu 12.04 | Postgres 8.4 | Apache Tomcat 7.0.x | JDK 7 | 2 GB | 2 GB | IE 11+ Firefox 25.01 |
| 3.2 | Windows 2003 R2 CentOS 6.5 (~Red Hat Enterprise Linux 6.4) Ubuntu 12.04 LTS | Postgres 8.4 | Apache Jakarta Tomcat 6.0.32 or 7.0.42 (recommended) | JDK 6 or JDK 7 (recommended) | 256 MB minimum 2 GB recommended | 500 MB minimum 2 GB recommended | IE 11 Firefox 25 |
| 3.1 | Windows 2003 Red Hat Enterprise Linux 4.0 CentOS Ubuntu | Postgres 8.4 (recommended) Oracle 10g | Apache Jakarta Tomcat 6.0.32 | JDK 6 | 256 MB minimum 2 GB recommended | 500 MB minimum 2 GB recommended | IE 7 or 8 Firefox 3.0+ |