OpenClinica has a flexible architecture that can run on numerous infrastructure combinations. Recent production versions of OpenClinica have been verified to run on the following components:
| Version | Server OS | Database | Application Server | Language | Memory | Disk | Client Browser |
| 3.1 | Windows 2003 Red Hat Enterprise Linux 4.0 CentOS Ubuntu | Postgres 8.4 (recommended) Oracle 10g | Apache Jakarta Tomcat 6.0.32 | JDK 6 | 256 MB minimum 2 GB recommended | 500 MB minimum 2 GB recommended | IE 7 or 8 Firefox 3.0+ |
| 3.2 | Windows 2003 R2 CentOS 6.5 (~Red Hat Enterprise Linux 6.4) Ubuntu 12.04 LTS | Postgres 8.4 | Apache Jakarta Tomcat 6.0.32 or 7.0.42 (recommended) | JDK 6 or JDK 7 (recommended) | 256 MB minimum 2 GB recommended | 500 MB minimum 2 GB recommended | IE 11 Firefox 25 |
| 3.3 |
RHEL/CentOS Windows 2003 R2 or above Ubuntu 12.04 | Postgres 8.4 | Apache Tomcat 7.0.x | JDK 7 | 2 GB | 2 GB | IE 11+ Firefox 25.01 |
| 3.4 | RHEL/CentOS Windows 2003 R2 or above Windows 2008 Ubuntu 12.04 | Postgres 8.4 | Apache Tomcat 7.0.x | JDK 7 | 2 GB | 2 GB | IE 11+ Firefox 30.0 |