1. Ensure your system complies with software dependencies and system requirements.
  2. Back up OpenClinica.
  3. Upgrade OpenClinica.
  4. Configure OpenClinica:
    1. Ensure that OpenClinica is configured for optimum performance as described here: Configure OpenClinica for Optimum Performance.
    2. You may also need to configure OpenClinica for internationalization should you wish to utilize OpenClinica in different languages. Also, if you need to use some UTF-8 characters in your application, you may need to modify your default connecter configuration. For more information regarding configuring OpenClinica for internationalization and using UTF-8 characters, please refer to https://docs.openclinica.com/3.1/technical-documents/openclinica-and-internationalization
  5. Verify the upgrade.
  6. Make manual updates to the database. The instructions are the same as for upgrading OpenClinica on Linux systems, except the README file on Windows systems is located at: